Product Introduction
Carboxymethyl-β-cyclodextrin is obtained by nucleophilic substitution of hydroxyl groups on the β-cyclodextrin ring with chloroacetic acid in an alkaline medium. It is a commonly used chiral additive in CE. As an anionic β-cyclodextrin derivative, carboxymethyl-β-cyclodextrin migrates in the opposite direction to the electroosmotic flow and the migration direction of two weakly alkaline analytes. Studies have shown that this countercurrent migration is conducive to chiral recognition, and that countercurrent migration increases the interaction time of the chiral selector and the analyte in the separation channel. It also shows that the chiral recognition process of cyclodextrin is not only the formation of inclusion complexes, but also weak interactions including electrostatic interactions play an important role.
Product Application
1.Pharmaceutical industry:
Drug solubilization and sustained release: encapsulate hydrophobic drugs (such as paroxetine, steroids), improve bioavailability, reduce drug dosage and side effects.
Formulation optimization: can used for oral or injection, enhance drug stability and prolong release time.
2.Food and cosmetics:
Functional improvement: encapsulate vitamins, flavors and other ingredients, cover up odors (such as bitterness, fishy smell), and improve product stability and taste.
Mild formulation: reduce the irritation of whitening agents, antioxidants and other ingredients, and extend the shelf life of cosmetic active ingredients.
