Product Application
1. Aquaculture
Florfenicol is the main therapeutic drug for bacterial diseases in aquatic animals, but its poor natural water solubility limits its efficacy. After inclusion with cyclodextrin:
1) Improve drug absorption efficiency: the inclusion compound can be quickly dissolved in water and efficiently absorbed by aquatic animals through gills and skin, enhancing the therapeutic effect on bacterial diseases.
2) Improve the convenience of administration: It is suitable for spraying or bathing, solving the problem of drug waste caused by poor solubility of traditional preparations.
2. Animal Husbandry and Veterinary Field
In the treatment of bacterial infections in terrestrial animals such as pigs, cattle, and poultry, the advantages of inclusion compounds include:
1) Enhance oral bioavailability: by inclusion with cyclodextrin derivatives and combined with absorption enhancers, the dissolution and absorption rate of florfenicol in the intestine are significantly improved.
2) Reduce side effects: the inclusion technology can mask the odor of the drug and reduce irritation to the gastrointestinal tract through sustained release.
Indications: Mainly used to treat digestive and respiratory infections caused by Escherichia coli, Salmonella, etc.
3. Drug preparation development
The optimization of the preparation process of inclusion complexes has promoted the research and development of new veterinary drug preparations
1) Process innovation: such as the ultrasonic-centrifugal drying method combined with high-temperature dissolution and high-speed centrifugation, which makes the water solubility of the inclusion complex reach 5000 ppm (25°C) and the yield exceeds 98%, which is suitable for industrial production.
2) Diversification of dosage forms: It can be made into soluble powder, granules, tablets, etc. to meet different dosing needs.
3) Improved stability: After inclusion, the light resistance and antioxidant degradation ability of florfenicol are enhanced, which prolongs the drug’s shelf life.
4. Environmental protection and food safety
1) Reduce drug residues: Due to the increase in bioavailability, the dosage can be reduced, thereby reducing the accumulation of drugs in water and animals, which meets environmental protection requirements.
2) Applicability to food animals: As a safe alternative to chloramphenicol, florfenicol inclusion complexes are safer in treating food animal infections and avoid the risk of aplastic anemia.
